A confederacy of kinases: Cdk2 and Cdk4 conspire to control embryonic cell proliferation.
نویسنده
چکیده
The mouse embryo is surprisingly resistant to loss of individual cyclins or cyclin-dependent kinases. In a recent issue of Developmental Cell, Berthet et al. (2006) describe collaboration of Cdk2 and Cdk4 in embryogenesis that is revealed only upon their simultaneous loss, resulting in inappropriate activation of the retinoblastoma protein and embryonic lethality.
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عنوان ژورنال:
- Molecular cell
دوره 22 4 شماره
صفحات -
تاریخ انتشار 2006